Intravitreal Avastin Injection for the Treatment of Choroidal Neovascularization Secondary to Pattern Dystrophy
试验速览
- 阶段
- 2 期
- 入组人数
- 5
- 试验地点
- 2
- 主要终点
- number of eyes with <15 letter loss (approximately <3 lines) at 6-month examination compared with the baseline value
研究概览
简要总结
The natural history of subfoveal CNV secondary to Pattern Dystrophy is little understood, but it seems that visual function may be preserved only in the short-term follow-up, with progressive deterioration thereafter.
Photodynamic therapy with verteporfin is the most studied therapeuthic option for this kindf of lesion, but unfortunately, this approach does not appear to guarantee long-term vision stabilization, and alternative therapies should be investigated.
详细描述
Diagnosis of Pattern Dystrophy Diagnosis of subfoveal CNV Intravitreal injection of avastin (1.25 mg) in operating room under sterile condition.
Retreatment on the basis of the detection of disease progression and of lack of central retinal thickness reduction on OCT.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- Single
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •diagnosis of RPD (hyperpigmented yellowish-greyish network, other family members sharing RPD, normal electroretinogram and normal/subnormal electrooculogram)
- •classic or occult CNV involving the foveal avascular zone's geometric centre
排除标准
- •conditions other than RPD
- •intraocular surgery or capsulotomy within the last 2 or 1 months
- •pregnancy
结局指标
主要结局
number of eyes with <15 letter loss (approximately <3 lines) at 6-month examination compared with the baseline value
numeber of eyes with <15 letter loss at 12-month examinations, compared with the baseline value.
次要结局
- CNV progression
- number of injections.