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Effects of Exercise Training in Bariatric Patients

Not Applicable
Conditions
Obesity
Interventions
Other: Exercise training
Registration Number
NCT02441361
Lead Sponsor
University of Sao Paulo
Brief Summary

Bariatric surgery may attenuate insulin resistance and low-grade inflammation in obese subjects. This trial aims to test whether exercise training can add to the benefits of bariatric surgery on insulin sensitivity and inflammation. In addition, this study aims to investigate whether exercise training can counteract bone loss induced by bariatric surgery.

Detailed Description

Not available

Recruitment & Eligibility

Status
UNKNOWN
Sex
Female
Target Recruitment
60
Inclusion Criteria
  • body mass index ≥ 35 kg/m2
  • not engaged in physical activity programs
  • without any physical limitation that could preclude exercise participation
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Exclusion Criteria
  • body mass index < 35 kg/m2
  • regular participation in physical activities programs
  • cancer or any other disease that could limit participation in exercise
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Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
exercise trainingExercise trainingSubjects will undergo bariatric surgery and exercise training will be prescribed.
Primary Outcome Measures
NameTimeMethod
insulin sensitivity as assessed by surrogates of insulin sensitivity6 months
body composition as assessed by densitometry (DEXA)6 months

bone mass, lean mass and fat mass

profile of cytokines6 months
Secondary Outcome Measures
NameTimeMethod
quality of life as assessed by questionnaires (composite)6 months
muscle function as assessed by a battery of tests6 months

timed-stands test, timed-up-ang-go test, maximal strength tests

depression and anxiety as assessed by questionnaires (composite)6 months
risk of cardiovascular events as assessed by questionnaires (composite)6 months
physical activity level as assessed by accelerometry6 months
aerobic conditioning as assessed by a cardiopulmonary test.6 months

Trial Locations

Locations (1)

University of Sao Paulo

🇧🇷

Sao Paulo, Brazil

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