Comparison of postoperative analgesic effect of clonidine through intravenous administration versus wound infiltration in patients undergoing open cholecystectomy
试验速览
- 阶段
- Unknown
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Postoperative pain and analgesic requirement
研究概览
简要总结
This randomized double- blind study was conducted to compare the postoperative analgesic effect of clonidine when administered intravenously or in wound infiltration with bupivacaine. 60 adult patients of ASA grade I-II undergoing elective open cholecystectomy were randomly allocated into three groups. Group 1 (control group) patients received wound infiltration with 30 ml 0.25% bupivacaine at the end of surgery. Group 2 patients received 3 mcg/kg clonidine IV plus wound infiltration with bupivacaine, while group 3 patients received 3 mcg/kg clonidine in would infiltration with bupivacaine. Postoperative analgesia was provided with intravenous diclofenac 8 hourly and morphine on demand. The postoperative pain, number of patients requiring rescue analgesia and total morphine consumption during 24 postoperative hours was recorded. Patients were observed for any adverse effects like excessive sedation, nausea-vomiting, hypotension and bradycardia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients posted for elective open cholecystectomy under general anesthesia.
排除标准
- •Patients with ASA physical status 3 or 4, Patients with morbid obesity, patients receiving adrenoceptor agonist, antagonist or narcotics.
结局指标
主要结局
Postoperative pain and analgesic requirement
时间窗: 24 postoperative hours
次要结局
- Side effects, like sedation, nausea-vomiting, hypotension and bradycardia(Patients satisfaction score)