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临床试验/NCT00889577
NCT00889577已完成不适用

Coronary Artery Disease and Its Association With Liver Steatosis Among HIV-Infected Persons

Henry M. Jackson Foundation for the Advancement of Military Medicine1 个研究点 分布在 1 个国家目标入组 233 人开始时间: 2008年12月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
233
试验地点
1
主要终点
Coronary artery disease (CAD) measured by the CAC score

研究概览

简要总结

The primary purpose of this study is to evaluate the association between nonalcoholic fatty liver disease (NAFLD) by computed tomography (CT) scan and coronary artery disease (CAD) measured by the calcium (CAC) score among HIV-infected persons.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Cross Sectional

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • HIV patients who participated in our previous Liver Study, conducted at NMCSD, and HIV patients who did not participate in the Liver Study.

排除标准

  • Women who are pregnant or breastfeeding will be excluded.

结局指标

主要结局

Coronary artery disease (CAD) measured by the CAC score

时间窗: 1 year

次要结局

  • To measure the pulmonary artery size to evaluate for prevalence of asymptomatic pulmonary hypertension among HIV-infected persons(1 year)
  • To evaluate predictors for coronary artery disease including demographics, concurrent conditions (e.g., diabetes, hyperlipidemia, tobacco use), and HIV factors such as ARV duration, HIV duration, and lipodystrophy(1 year)
  • To investigate the relationship between inflammatory markers (CRP, ESR), d-dimer, adiponectin levels, future inflammatory markers, and genetic polymorphisms with the presence of coronary disease and NAFLD(1 year)
  • To assess the relationship between increased pericardial fat on CT scan with visceral fat and cardiovascular disease(1 year)
  • To determine the prevalence of coronary artery disease as determined by computed tomography (CT) of the coronary arteries among HIV patients, and to compare it to data from the general population using normative data from recent publications(1 year)
  • To determine if Hounsfield units taken in the heart and aorta estimates hemoglobin levels(1 year)
  • To describe the outcome of a positive CAC score in terms of follow-up test/procedure results to help describe the clinical significance of elevated scores.(1 year)

研究者

发起方
Henry M. Jackson Foundation for the Advancement of Military Medicine
申办方类型
Other
责任方
Sponsor

研究点 (1)

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