Dysfunctional Lens Index Serves as a Novel Surgery Decision Maker for Age-related Cataracts
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Wenzhou Medical University
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Dysfunctional lens index
Study Overview
Brief Summary
To study the correlations among the dysfunctional lens index (DLI), Lens Opacities Classification System III (LOCS III) nuclear opalescence grading score, preoperative corrected distance visual acuity (CDVA), the objective scatter index (OSI) and Scheimpflug based average lens density in age-related cataracts. To investigate the potential of the DLI as a novel surgery decision maker via the Operating Characteristic (ROC) curve analysis.
Detailed Description
Each patient received a comprehensive eye examination, including corrected distance visual acuity (CDVA) preoperatively and the day after surgery, subjective refraction, slit-lamp evaluation, noncontact tonometry (TX-F; Cannon, Tokyo, Japan), and dilated fundus examination. According to the surgery decision made by the three surgeons based on the slit lamp biomicroscopy and CDVA, patients were divided into two groups: Surgical and Non-Surgical. The results of the DLI, OSI and average lens density (ALD) were masked to the surgeons. The DLI, OSI, average lens density, LOCS III nuclear opalescence grading, and preoperative CDVA were obtained. Correlations among these parameters were analyzed. ROC curves were used to analyze DLI values to determine a value to separate between surgical and non-surgical cataracts.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Screening
- Masking
- None
Eligibility Criteria
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •patients with age-related cataracts
Exclusion Criteria
- •any corneal opacity, corneal dystrophies, retinal anomalies, a history of ocular surgery or laser treatment, a LOCS III grade of cortical opacity ≥ 3.0 or posterior subcapsular cataract ≥ 2.0.
Arms & Interventions
cataract surgery
cataract extraction and intraocular implantation
Intervention: a ray-tracing aberrometry (Procedure)
Outcomes
Primary Outcomes
Dysfunctional lens index
Time Frame: 6 months
The DLI is an objective lens performance metric derived from internal higher order aberrations (HOAs), pupil size, and contrast sensitivity data
Secondary Outcomes
No secondary outcomes reported
Investigators
yin ying zhao
Director
Wenzhou Medical University