This is a study to establish the role of 3 biomarkers (Procalcitonin, Interleukin-6 and sTREM-1) for supporting the diagnosis and prognosis(outcome) in infection (sepsis) in critically ill patients
Not Applicable
- Conditions
- Health Condition 1: - Health Condition 2: A00-B99- Certain infectious and parasitic diseases
- Registration Number
- CTRI/2018/12/016503
- Lead Sponsor
- Self
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patients 18 years of age or older admitted in various intensive care units (ICUs) of All India Institute of Medical Sciences from July 2017 to June 2019 who fulfil the definition of sepsis or SIRS will be enrolled for the study. Patients who develop new onset sepsis or septic shock in ICU will also be included in the study
Exclusion Criteria
Patients who received treatment with Corticosteroids or immunomodulators in previous 6 months
Patients with malignancy, immunodeficiency or organ transplant recipients
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the role of Serum Procalcitonin, Interleukin-6 and sTREM-1 levels in differentiating patients with sepsis from patients with non-infectious systemic inflammatory response syndrome (NI-SIRS)Timepoint: Day 1 to Day 3
- Secondary Outcome Measures
Name Time Method To establish the role of Serum Procalcitonin, IL-6 and sTREM-1 levels in prognosis in patients with sepsisTimepoint: Day of admission to ICU to discharge or death of the patient