The Vasopressin Loading for Refractory septic shock (VALOR) study (VAROLstudy)
- Conditions
- septic shock
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 250
(1) Age at enrollment is 20 years or older
(2) Patients diagnosed with septic shock based on Sepsis-3 (requiring noradrenaline or other hypertensive drugs to maintain an average blood pressure of 65 mmHg or higher despite adequate infusion load, and blood lactate level of 2 mmol/L or higher)
(3) Patients receiving noradrenaline 0.2 gamma or higher
(1) Participated in this clinical study in the past (2) Patients who are otherwise judged by the physician to be inappropriate for inclusion in the study (3) Patients for whom the administration of this drug is contraindicated (4) Patients who cannot find a surrogate and whose state of consciousness is not expected to improve
Study & Design
- Study Type
- Interventional
- Study Design
- parallel assignment
- Primary Outcome Measures
Name Time Method - Lactate change before and 2 hours after administration
- Secondary Outcome Measures
Name Time Method Adverse events limb/intestinal/myocardial ischemia, 30-day in-hospital deaths