A Biobehavioral Model of Diabetes Risk in Chinese Immigrants

Completed

• Conditions: Diabetes Mellitus, Type 2

• Registration Number: NCT02449213
• Lead Sponsor: Fox Chase Cancer Center

Brief Summary

This prospective, longitudinal study of Chinese American immigrants will examine whether psychosocial factors (e.g., acculturative stress, social isolation, discrimination) are associated with markers of type 2 diabetes risk over time, and whether such associations are mediated by inflammatory pathways.

Detailed Description

It is now well-documented that immigration to the US leads to increased risk for various chronic diseases, including type 2 diabetes. The increased diabetes risk observed among Chinese immigrants has been primarily attributed to changes in diet and weight gain following immigration, but these changes can only partially explain disparities in disease risk. Models of immigrant health suggest that the stress of adapting to life in a new country has a considerable impact on physical health. However, few studies have considered the psychosocial impact of immigration upon biomarkers of health and disease risk. Therefore, this longitudinal study of US Chinese immigrant men and women will examine: (1) whether psychosocial factors (e.g., acculturative stress, social isolation, discrimination) are associated with markers of type 2 diabetes risk over time; and (2) whether the association between psychosocial factors and diabetes risk markers is mediated by inflammatory pathways.

Study Timeline

• Study First Submitted: 2015-05-17
• Study First Submitted QC: 2015-05-17
• Study First Posted: 2015-05-20
• Study Start: 2016-03-11
• Primary Completion: 2021-05-05
• Study Completion: 2021-05-05
• Status Verified: 2021-06
• Last Update Submitted: 2021-06-02
• Last Update Posted: 2021-06-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 650

Inclusion Criteria

• Chinese heritage;
• migration from Asia in adulthood (aged 18 years or older); and
• age 35-65 years

Exclusion Criteria

• Current or prior history of diabetes
• Self-reported conditions of cancer, auto-immune disorders, HIV, or psychiatric illness
• Use of medications that may impact study outcomes (e.g., steroidal or non-steroidal anti-inflammatory medications)
• Inability to provide informed consent.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Insulin resistance	24 months post-baseline	Insulin resistance will be estimated according to the homeostasis model assessment (HOMA) as HOMA = (fasting insulin x fasting glucose) / 22.5

Secondary Outcome Measures

Name	Time	Method
glycated hemoglobin (HbA1c)	24-months post-baseline	Level of blood sugar

Trial Locations

Locations (1)

Fox Chase Cancer Center; 🇺🇸 Philadelphia, Pennsylvania, United States