Effetivity of Dutasteride and Aloe Vera Extract Combination on Angiogenesis and Obstruction on Benign Prostatic Hyperplasia
Not Applicable
Recruiting
- Conditions
- BPH (Benign Prostatic Hyperplasia)
- Interventions
- Drug: Aloevera + dutasteride
- Registration Number
- NCT07065682
- Lead Sponsor
- Universitas Diponegoro
- Brief Summary
This study is a double blinded RCT with pre-post test design on the effect of combination of dutasteride and aloe vera, compared to dutasteride only, on uroflowmetry results, prostate volume, and VEGF serum level among patients with benign prostate hyperplasia. The treatment was given for 12 weeks
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- Male
- Target Recruitment
- 84
Inclusion Criteria
- Diagnosed with BPH clinically or radiologically (prostate volume > 30 gram, Qmax <15 mL/s)
- Willing to participate to the study
Exclusion Criteria
- Clinically or radiologically suspected of having prostatic cancer
- Previous prostatic surgery
- Patients with urinary retention
- Patients with BPH complications: urinary tract infections, urolithiasis, or hydroneprhosis
- Previously consumed alpha blocker or 5ARI in the last 6 months
- Have consumed aloe vera extract routinely
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Dutasteride 0,5 mg/day + Aloe Vera Extract 380 mg/day Aloevera + dutasteride - Dutasteride Dutasteride (0.5mg) Control
- Primary Outcome Measures
Name Time Method Uroflowmetry result 12 weeks Qmax of Uroflowmetry result
- Secondary Outcome Measures
Name Time Method Prostatic volume 12 weeks Measured by transabdominal ultrasonography
VEGF 12 weeks serum VEGF level
Trial Locations
- Locations (1)
RSUD Karawang
🇮🇩Karawang, West Java, Indonesia
RSUD Karawang🇮🇩Karawang, West Java, IndonesiaAchmad Rizky Herda Pratama dr. Achmad Rizky Herda Pratama, Sp.U, S.H, UrologistPrincipal Investigator