Effects of butyrate compared to donor faeces transplantation on metabolism and satiety in patients with metabolic syndrome - APPETITE study

Academisch Medisch Centrum0 个研究点目标入组 36 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

暂无简介。

•- Caucasian male or postmenopausal female
•- 50-70 years old
•- BMI *30 kg/m2
•- At least 3 out of 5 NCEP metabolic syndrome criteria: fasting plasma glucose * 5.6 mmol/l, triglycerides * 1.7 mmol/l, waist-circumference > 102 cm (m) / > 88 cm (f), HDL-cholesterol * 1.04 mmol/l (m) / * 1.30 mmol/l (f), blood pressure * 130/85 mmHg

•- Medication use, including PPI and antibiotics in last 3 months
•- Smoking, XTC, amphetamine or cocaine abuse
•- Alcohol abuse (>3/day)
•- Participation in a research protocol involving radiation exposure in the last 2 years.
•- eGFR <60 ml/min
•- Contraindication MRI
•- History of cardiovascular event (MI or pacemaker implantation)
•- Cholecystectomy
•- Expected prolonged compromised immunity (due to recent cytotoxic chemotherapy or HIV infection with a CD4 count < 240)

发起方