Comparing ondansetron and placebo for the reduction of spinal anesthesia-induced hypotension, a double blind randomized control trial
Phase 4
- Conditions
- HypotensionBradycardiaHypotensionBradycardiaOndansetron5-HT3 receptor antagonist
- Registration Number
- TCTR20200327001
- Lead Sponsor
- /A
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending (Not yet recruiting)
- Sex
- All
- Target Recruitment
- 110
Inclusion Criteria
1.Patients aged 18-65
2.Patients of American Society of Anesthesiologists (ASA) physical status, I or II scheduled for elective urologic, orthopedic or gynecologic surgeries under spinal anesthesia
Exclusion Criteria
1.Refused to participate in the research
2.Emergency case
3.Contraindication for spinal block
4.Allergic to ondansetron and local anesthetic drugs
5.Patients with these underlying diseases (hypertension, heart disease, kidney disease, liver disease, neurological and brain disease).
6.History of serotonin drug used
7.Language barrier
8.Pregnancy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Hypotension every 3 minutes until 30 minutes after spinal block Mean arterial pressure decrease > 20% from baseline
- Secondary Outcome Measures
Name Time Method Bradycardia every 3 minutes until 30 minutes after spinal block less than 45 beats per minutes