Evaluation of Oxygen Consumption and Energy Expenditure During Spontaneous Breathing Trial.

Not Applicable

Completed

• Conditions: Respiratory Failure
• Interventions: Device: Automatic Tube Compensation plus CPAP; Device: Continuous Positive Airway Pressure

• Registration Number: NCT01757093
• Lead Sponsor: University of Sao Paulo

Brief Summary

The purpose of this study is to compare the oxygen consumption and energy expenditure during the spontaneous breathing trial.

Detailed Description

Patients is going to submit to the 2 spontaneous breathing trial ( Automatic tube compensation plus continuous positive airway pressure and continuous positive airway pressure without automatic tube compensation. The oxygen consumption and energy expenditure is going to measure during the spontaneous breathing trial by indirect calorimetry.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2012-06
• Study First Submitted: 2012-12-17
• Study First Submitted QC: 2012-12-20
• Study First Posted: 2012-12-28
• Primary Completion: 2013-09
• Study Completion: 2013-09
• Status Verified: 2014-11
• Last Update Submitted: 2014-11-25
• Last Update Posted: 2014-12-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• IMPROVEMENT OR RESOLUTION OF THE UNDERLYING CAUSE OF DISEASE
• INTUBATED PATIENTS>24h
• PaO2 GREATER THAN 60 mmHg WITH FiO2 LESS THAN 40%
• PEEP=5 cmH2O

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Exclusion Criteria

• CARDIOVASCULAR INSTABILITY
• FEBRILE OR HYPOTHERMIA
• CHEST DRAINAGE
• RESPIRATORY RATE/TIDAL VOLUME RATIO GREATER THAN 105
• PREGNANCY
• FAIL IN THE SPONTANEOUS BREATHING TRIAL
• LEAKS IN THE CIRCUIT
• AGITATION
• NOT ACCEPT PARTICIPATE IN THE STUDY

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Automatic tube compensation plus CPAP	Automatic Tube Compensation plus CPAP	The patients is going to undergo trials of spontaneous breathing with automatic tube compensation plus continuous positive airway pressure and later a trial with continuous positive airway pressure. During 30 minutes.
Automatic tube compensation plus CPAP	Continuous Positive Airway Pressure	The patients is going to undergo trials of spontaneous breathing with automatic tube compensation plus continuous positive airway pressure and later a trial with continuous positive airway pressure. During 30 minutes.
Continuous Positive Airway Pressure	Continuous Positive Airway Pressure	The patients is going to undergo a trial of spontaneous breathing with continuous positive airway pressure and later with automatic tube compensation plus continuous positive airway pressure, during 30 minutes each.
Continuous Positive Airway Pressure	Automatic Tube Compensation plus CPAP	The patients is going to undergo a trial of spontaneous breathing with continuous positive airway pressure and later with automatic tube compensation plus continuous positive airway pressure, during 30 minutes each.

Primary Outcome Measures

Name	Time	Method
Measurement of oxygen consumption through indirect calorimetry.	The measurement is during the spontaneous breathing trial, 30 minutes.	Measurements using indirect calorimetry for determination of oxygen consumption

Secondary Outcome Measures

Name	Time	Method
Measurement of energy expenditure through indirect calorimetry	The measurement is during the spontaneous breathing trial, 30 minutes.	Measurement using indirect calorimetry for determination of energy expenditure.

Trial Locations

Locations (1)

Hospital Das Clínicas Da Faculdade de Medicina de Ribeirão Preto -Universidade de São Paulo; 🇧🇷 Ribeirão Preto, São Paulo, Brazil