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Clinical Trials/NCT06409507
NCT06409507CompletedNot Applicable

The Impact of FKBP12 on the Prognosis and Sirolimus Administration in Liver Transplantation Recipients With Hepatocellular Carcinoma: A Single-center Retrospective Cohort Study

First People's Hospital of Hangzhou0 sites178 target enrollmentStarted: January 1, 2015Last updated:
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Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Sponsor
Enrollment
178
Primary Endpoint
Overall survival
Study OverviewStudy DesignEligibility CriteriaOutcomesInvestigatorsRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

The study evaluated the protein expression levels of FK506-binding protein 12 (FKBP12) in hepatocellular carcinoma (HCC) and paracancerous tissues using immunohistochemistry (IHC). This study aimed to determine the role of FKBP12 in the outcome of liver transplantation recipients with HCC, especially those exceeding the Milan criteria. In addition, we explored how sirolimus administration affected LT recipients'prognosis depending on different FKBP12 expression, aiming to provide some advice for clinical sirolimus application after LT.

Study Design

Study Type
Observational
Observational Model
Cohort
Time Perspective
Retrospective

Eligibility Criteria

Ages
18 Years to 75 Years (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •(1) pathologically confirmed HCC (2) full post-LT follow-up record

Exclusion Criteria

  • •(1)sirolimus treatment less than 30 days or after tumor recurrence (2)died within 90 days (3)underwent multiple-organ transplantation

Outcomes

Primary Outcomes

Overall survival

Time Frame: 2015.1.1-2021.1.1

the length of months between surgery and the last follow-up or death

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor
First People's Hospital of Hangzhou
Sponsor Class
Other
Responsible Party
Sponsor

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