Effect of Vitamin B12 on the Development of Sepsis, in Culture Positive Patients

Completed

• Conditions: Bacteremia

• Registration Number: NCT04008446
• Lead Sponsor: University of Zurich

Brief Summary

This is an prospective observational study assessing the effect of vitamin B12 on the odds of developing sepsis in patients with infection confirmed by a positive culture result.

The hypothesis is that patients with infection confirmed by positive cultures who develop sepsis have lower vitamin B12 levels than patients infection, confirmed by positive cultures, who do not develop sepsis.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-06-01
• Study First Submitted: 2019-06-17
• Study First Submitted QC: 2019-07-03
• Study First Posted: 2019-07-05
• Primary Completion: 2022-11-11
• Study Completion: 2022-12-31
• Status Verified: 2023-01
• Last Update Submitted: 2023-01-09
• Last Update Posted: 2023-01-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Adults (≥18 years old)
• Infection, confirmed by a positive culture result
• Signed informed consent.

Exclusion Criteria

• Pregnancy and/or breast feeding
• Inability to follow the procedures of the study, due to language problems, psychological disorders, social conditions or dementia

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Holotranscobalamin (HTC) levels	6 days	HTC levels in patients with infection and sepsis compared to patients with infection without sepsis.

Secondary Outcome Measures

Name	Time	Method
Vitamin B12 levels	6 days	Levels of vitamin B12 in patients with infection and sepsis compared to patients with infection without sepsis
Methylmalonic acid (MMA) levels	6 days	Levels of ethylmalonic acid (MMA) in patients with infection and sepsis compared to patients with infection without sepsis

Trial Locations

Locations (1)

University Hospital of Zurich; 🇨🇭 Zurich, Switzerland