Sweet Taste Responsiveness in Relation to Insulin, Leptin and Adiposity Among Obese Treatment Seeking Children

Not Applicable

Withdrawn

• Conditions: Pediatric Obesity
• Interventions: Diagnostic Test: Serum insulin level; Diagnostic Test: Serum Leptin test

• Registration Number: NCT04600648
• Lead Sponsor: State University of New York at Buffalo

Brief Summary

This study will explore whether a relationship exists between insulin and leptin resistance, sweet taste responsiveness, and adiposity.

Detailed Description

Compared to healthy weight peers, some reports have shown that they are less sensitive to, or perceptive of, sucrose solutions and sweet foods, whereas others have observed the opposite pattern of findings or no difference at all. Among those seeking weight loss treatment, one investigation found perception and preferences for sweet taste remained unchanged after weight loss, and another observed a decreased ability to distinguish sweet taste from other taste solutions. Given these discrepancies in the literature, the proposed study will explore whether a relationship exists between insulin and leptin resistance, sweet taste responsiveness, and adiposity.

Study Timeline

• Study Start: 2018-09-20
• Primary Completion: 2019-08-02
• Study Completion: 2019-08-02
• Study First Submitted: 2019-08-26
• Status Verified: 2020-10
• Study First Submitted QC: 2020-10-19
• Study First Posted: 2020-10-23
• Last Update Submitted: 2023-06-22
• Last Update Posted: 2023-06-26

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Patient of Children's Healthy Weigh of Buffalo
• ages of 8-14

If enrolled in the bariatric arm:

• must be scheduled for bariatric surgery prior to enrollment

Exclusion Criteria

• Patients unable to get labs drawn at a Kaleida facility
• Severe hay fever or seasonal allergies within 2 weeks of enrollment
• smoker or are exposed to second-hand smoke at home,
• has been dieting to lose weight within the past 6 months of enrollment
• currently taking any prescription medications that can influence taste or small functions or are pregnant.
• pregnancy
• Bariatric arm patients will be excluded if they fail to have the surgery.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Weight loss with bariatric surgery	Serum insulin level	Patients scheduled to undergo bariatric surgery will be tested pre and post bariatric surgery. Interventions to be measured are serum Insulin and leptin levels, sweet taste responsiveness, body fat percentage, and z-BMI
Weight Loss	Serum Leptin test	Patients to receive lifestyle weight loss treatment will be tested pre and post bariatric surgery. Interventions to be measured are serum Insulin and leptin levels, sweet taste responsiveness, body fat percentage, and z-BMI

Primary Outcome Measures

Name	Time	Method
Higher insulin and leptin levels will be associated with lower sweet taste sensitivity and perception, and higher body fat percentage and z-BMI	to be measured at 6 months	insulin and leptin levels will be measured at various time points in an attempt to identify if there is a change is taste senses associated with specific variables be associated with lower sweet taste