Sweet Taste Responsiveness in Relation to Insulin, Leptin and Adiposity Among Obese Treatment Seeking Children
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 主要终点
- Higher insulin and leptin levels will be associated with lower sweet taste sensitivity and perception, and higher body fat percentage and z-BMI
研究概览
简要总结
This study will explore whether a relationship exists between insulin and leptin resistance, sweet taste responsiveness, and adiposity.
详细描述
Compared to healthy weight peers, some reports have shown that they are less sensitive to, or perceptive of, sucrose solutions and sweet foods, whereas others have observed the opposite pattern of findings or no difference at all. Among those seeking weight loss treatment, one investigation found perception and preferences for sweet taste remained unchanged after weight loss, and another observed a decreased ability to distinguish sweet taste from other taste solutions. Given these discrepancies in the literature, the proposed study will explore whether a relationship exists between insulin and leptin resistance, sweet taste responsiveness, and adiposity.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 8 Years 至 14 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient of Children's Healthy Weigh of Buffalo
- •ages of 8-14
- •If enrolled in the bariatric arm:
- •must be scheduled for bariatric surgery prior to enrollment
排除标准
- •Patients unable to get labs drawn at a Kaleida facility
- •Severe hay fever or seasonal allergies within 2 weeks of enrollment
- •smoker or are exposed to second-hand smoke at home,
- •has been dieting to lose weight within the past 6 months of enrollment
- •currently taking any prescription medications that can influence taste or small functions or are pregnant.
- •pregnancy
- •Bariatric arm patients will be excluded if they fail to have the surgery.
结局指标
主要结局
Higher insulin and leptin levels will be associated with lower sweet taste sensitivity and perception, and higher body fat percentage and z-BMI
时间窗: to be measured at 6 months
insulin and leptin levels will be measured at various time points in an attempt to identify if there is a change is taste senses associated with specific variables be associated with lower sweet taste
次要结局
未报告次要终点
研究者
Carroll M. Harmon, MD PhD
MD, Surgeon-in-Chief and Program Director
University at Buffalo