NCT01797601
Completed
Not Applicable
Insulinsensitivität Des Menschlichen Zentralnervensystems: Kernspintomographische Untersuchung Mit Intranasaler Gabe Von Insulin
Overview
- Phase
- Not Applicable
- Intervention
- Human Insulin
- Conditions
- Obesity
- Sponsor
- University Hospital Tuebingen
- Enrollment
- 48
- Locations
- 1
- Primary Endpoint
- Insulin effect on regional brain activity assessed by fMRI
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
The purpose of the study is to investigate whether insulin sensitivity and insulin resistance of the human brain is comparable in all insulin sensitive parts of the brain and whether correlates to other phenotypic information (i.e. whole body insulin sensitivity, BMI, age) of the study participants.
Investigators
andreas fritsche
Prof. Andreas Fritsche
University Hospital Tuebingen
Eligibility Criteria
Inclusion Criteria
- •Normal routine blood works
- •for women: negative pregnancy test
Exclusion Criteria
- •Type 2 diabetes
- •pregnancy
- •acute or chronic diseases
- •Pacemakers
- •Artificial heart valves
- •Metal prostheses
- •Implanted magnetic metal parts (screws, ...)
- •Metal fragments
- •insulin pumps
- •claustrophobia
Arms & Interventions
Human Insulin
Nasal spray
Intervention: Human Insulin
Placebo solution
Nasal spray
Intervention: Placebo
Outcomes
Primary Outcomes
Insulin effect on regional brain activity assessed by fMRI
Time Frame: Change from Baseline to 15 minutes and 60 minutes post spray application
Study Sites (1)
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