Influence of Brain Insulin Sensitivity on Peripheral Insulin Sensitivity

University Hospital Tuebingen1 site in 1 country10 target enrollmentApril 2013

ConditionsInsulin Sensitivity

Interventionshuman insulin as nasal spray Placebo

Drugshuman insulin as nasal spray Placebo

Overview

Phase: Not Applicable
Intervention: human insulin as nasal spray
Conditions: Insulin Sensitivity
Sponsor: University Hospital Tuebingen
Enrollment: 10
Locations: 1
Primary Endpoint: Insulin sensitivity as measured by clamp
Status: Completed
Last Updated: 12 years ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

The researchers will investigate if brain insulin action influences peripheral insulin sensitivity in healthy humans.

Registry

clinicaltrials.gov

Start Date

April 2013

End Date

November 2013

Last Updated

12 years ago

Study Type

Interventional

Study Design

Crossover

Sex

Male

Investigators

Sponsor

University Hospital Tuebingen

Responsible Party

Principal Investigator

andreas fritsche

Professor of Medicine

University Hospital Tuebingen

Eligibility Criteria

Inclusion Criteria

•BMI \< 28 kg/m2
•normal HbA1c
•healthy volunteers

Exclusion Criteria

•Heparin induced thrombocytopenia (HIT)
•metal implants
•cardial diseases
•patients taking any kind of drugs

Arms & Interventions

insulin nasal spray

160 Units of human insulin as nasal spray

Intervention: human insulin as nasal spray

Placebo nasal spray

Nasalspray containing placebo solution

Intervention: Placebo

Outcomes

Primary Outcomes

Insulin sensitivity as measured by clamp

Time Frame: 45 minutes to 120 minutes post nasal spray

We will measure insulin sensitivity by hyperinsulinemic euglycemic clamp before and after nasal spray application. We will compare the post-spray insulin sensitivity between the two condition (insulin nasal spray vs placebo nasal spray). Furthermore, we will compare insulin sensitivity before and after nasal insulin application.