Novel Treatment for Brain Insulin Resistance and Hypoperfusion
试验速览
- 阶段
- 早期 1 期
- 状态
- 暂停
- 入组人数
- 65
- 试验地点
- 1
- 主要终点
- Amount of cerebral blood flow
研究概览
简要总结
The purpose of this project is to examine the impact of increases in brain insulin on sympathetic nervous system activity, as well as peripheral and cerebral blood flow in humans.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy adult men and women;
- •18-45 years of age;
- •BMI >18 kg/m2;
- •non-pregnant/non-breastfeeding;
- •non-nicotine users;
排除标准
- •taking any medications known to affect metabolic, respiratory, cardiovascular, and/or autonomic
- •Self-reported history of:
- •hepatic, renal, pulmonary, cardiovascular, or neurological disease;
- •stroke or neurovascular disease;
- •bleeding/clotting disorders;
- •sleep apnea or other sleep disorders;
- •diabetes;
- •history of alcoholism or substance abuse;
- •hypertension;
- •respiratory disease;
- •active cancer;
- •autoimmune disease.
研究组 & 干预措施
Insulin (Doppler)
Human insulin (160 IU) will be administered as a bolus using an intra-nasal device.
干预措施: Carbon dioxide breathing (Other)
Insulin (Doppler)
Human insulin (160 IU) will be administered as a bolus using an intra-nasal device.
干预措施: Neurovascular Coupling (Other)
Insulin (Doppler)
Human insulin (160 IU) will be administered as a bolus using an intra-nasal device.
干预措施: Human insulin (Drug)
Insulin (MRI)
Human insulin (160 IU) will be administered as a bolus using an intra-nasal device.
干预措施: Carbon dioxide breathing (Other)
Insulin (MRI)
Human insulin (160 IU) will be administered as a bolus using an intra-nasal device.
干预措施: Human insulin (Drug)
Time Control (Doppler)
Time control only
干预措施: Carbon dioxide breathing (Other)
Time Control (Doppler)
Time control only
干预措施: Neurovascular Coupling (Other)
结局指标
主要结局
Amount of cerebral blood flow
时间窗: Change from baseline at minute 15
Measured with trans-cranial Doppler ultrasound (cm/s) or arterial spin labeling (mL/100 g/min)
次要结局
- Amount of leg blood flow(Change from baseline at minute 15)
- Amount of muscle sympathetic nerve activity (MSNA)(Change from baseline at minute 15)
研究者
Jacqueline K Limberg, PhD
Associate Professor
University of Missouri-Columbia