Effect of Propofol on Remifentanil-induced Postoperative Hyperalgesia in Patients Undergoing Thyroid Surgery
- Registration Number
- NCT01189721
- Lead Sponsor
- Gangnam Severance Hospital
- Brief Summary
The investigators hypothesize that propofol infusion during surgery can affect the remifentanil hyperalgesia compared to sevoflurane inhalation.The outcome will be measured by a verbal numerical rating score (VNRS) and mechanical punctuating pain by electronic von frey filament.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 84
Inclusion Criteria
- Patients undergoing thyroidectomy
- Age 20-65
- American Society of Anesthesiologists physical status classification I or II
Exclusion Criteria
- History of chronic pain, Regular use of analgesic, antiepileptic or antidepressive drugs
- History of drug & alcohol abuse
- Psychiatric disorder
- Use of opioids within 24hrs
- Renal disease with decreased glomerular filtrate ratio
- Neuromuscular disease, Severe cardiac disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description sevoflurane propofol, sevoflurane Remifentanil will be infused intraoperatively at 0.2 ㎍/㎏/min. patients who are in this group will be infused propofol intraoperatively. propofol propofol, sevoflurane Remifentanil will be infused intraoperatively at 0.2 ㎍/㎏/min. patients included this group will be inhaled sevoflurane intraoperatively.
- Primary Outcome Measures
Name Time Method Tactile pain thresholds adjacent to the surgical wound assessed by von Frey hair before the induction and at postoperative 24 & 48 hrs postoperative 48 hrs
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Gang Nam Severance Hospital, Yonsei University, Anesthesia and Pain Medicine Department,
🇰🇷Seoul, Korea, Republic of