The Effect of Adjunct Vitamin a on Community-Acquired Pneumonia in Southern Iranian Children: a Randomized Clinical Trial

Not Applicable

Completed

• Conditions: Community-Acquired Pneumonia; Vitamin a

• Registration Number: NCT06677684
• Lead Sponsor: Hormozgan University of Medical Sciences

Brief Summary

This randomized clinical trial included 105 children with CAP who were admitted to Bandar Abbas Children's Hospital. Participants were randomly assigned to two groups: a control group receiving standard antibiotic therapy and an intervention group receiving standard antibiotics plus vitamin A (25,000 IU for 2 days). Key data collected included age, sex, duration of hospitalization, treatment duration, and daily Respiratory Index of Severity in Children (RISC) scores.

Detailed Description

Children to present with CAP symptoms

Study Timeline

• Status Verified: 2021-02
• Study Start: 2021-02-01
• Primary Completion: 2021-09-01
• Study Completion: 2021-09-18
• Study First Submitted: 2024-11-01
• Study First Submitted QC: 2024-11-05
• Last Update Submitted: 2024-11-05
• Study First Posted: 2024-11-07
• Last Update Posted: 2024-11-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 105

Inclusion Criteria

• children to present with CAP symptoms, including fever, cough, pulmonary rales, respiratory distress (age-adjusted tachypnea: >50 breaths per minute for infants under 1 year, >40 for ages 1-5 years, and >30 for those over 5 years), and radiographic findings indicative of pneumonia.

Exclusion Criteria

• underlying immunodeficiency, chronic respiratory conditions, concurrent use of immunosuppressive medications, prior high-dose vitamin A intake, and hospitalizations shorter than 24 hours

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
duration of hospitalization	Key data collected included age, sex, duration of hospitalization, treatment duration, and daily Respiratory Index of Severity in Children (RISC) scores.	Vitamin A supplementation was associated with a significant reduction in hospitalization duration in children with CAP, supporting its potential as an adjunct therapy.
Treatment duration daily Respiratory Index of Severity in Children (RISC) scores	From enrollment to the end of treatment and discharge of patients ( 6 months)	daily Respiratory Index of Severity in Children (RISC) scores

Trial Locations

Locations (1)

Hormozgan University of Medical Sciences; 🇮🇷 Bandar Abbas, Hormozgan, Iran, Islamic Republic of