Evaluation of the preemptive and preventive use of coadministration of Ibuprofen l-arginine and Dexamethasone on postoperative inflammatory markers, quality of life, sleep quality and pain catastrophizing in lower third molar surgeries: a randomized, split-mouth, factorial, controlled clinical trial

niversidade Federal do Ceará0 个研究点开始时间: 2023年10月13日最近更新: 2023年11月13日

适应症

试验速览

暂无简介。

•Healthy individuals of both sexes; aged between 18-35 years; in need of removal of the two lower third molars; will be invited to participate in this study. In addition to these, the following inclusion criteria will also be adopted: semi-erupted or non-erupted mandibular third molars; third molars that present, on panoramic radiography, similar patterns of root formation, position and degree of impaction when comparing the right and left sides of each volunteer

•Volunteers who meet at least one of the following criteria will be excluded: smokers; pregnant or lactating women; users of medications that interact with the drugs used in this study; carriers of orthodontic bands in mandibular second molars; confirmed history of allergy to NSAIDs or corticoids; signs of any preoperative inflammatory or infectious condition; systemic diseases; neurological disorders. In addition, the volunteer who has used any NSAID or corticoid within a period of up to 21 days before the surgical procedure will also be excluded from the research due to the possibility of a residual effect of the drug eventually used, which may influence the outcomes of the present study

发起方

niversidade Federal do Ceará