CTRI/2021/07/034577
Recruiting
未知
To Evaluate the Safety and Efficacy of Preemptive Administration of Continuous Renal Replacement Therapy in Patients With Acute Liver Failure With Cerebral Edema -A Prospective Randomized Controlled Trial.
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Health Condition 1: K729- Hepatic failure, unspecified
- Sponsor
- Institute of Liver and Biliary Sciences
- Status
- Recruiting
- Last Updated
- 4 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients with acute liver failure defined patients with jaundice which is complicated by encephalopathy and coagulopathy within 4 weeks of the onset of jaundice and without underlying chronic liver disease with documented cerebral edema on CT\-scan and arterial ammonia \>150 ug/dL.
Exclusion Criteria
- •1\.Age \<18 or \> 70 years
- •2\.Hepatocellular Carcinoma
- •3\.Active untreated Sepsis/DIC
- •4\.Hemodynamic instability requiring high dose of vasopressors
- •5\.Post\-resection and malignancy related liver failure
- •6\.Coma of non\-hepatic origin
- •7\.Patients with post renal obstructive AKI, AKI suspected due to glomerulonephritis, interstitial nephritis or vasculitis based on clinical history and urine analysis
- •8\.Patients already meeting emergency criteria for immediate initiation of dialysis at the time of randomization (serum potassium \>6 meq/lt, metabolic acidosis ph \<7\.12, acute pulmonary edema, severe volume overload with hypoxemia non\-responsive to diuretic treatment)
- •9\.Patients transferred from other hospitals who have already been on hemodialysis before their arrival in the intensive care unit
- •10\.Extremely moribund patients with an expected life expectancy of less than 24 hours
Outcomes
Primary Outcomes
Not specified
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