Efficacy of Allergen Immunotherapy for Allergic Rhinitis in Thais
- Conditions
- Rhinitis, Allergic, Perennial
- Registration Number
- NCT01115595
- Lead Sponsor
- Pongsakorn Tantilipikorn
- Brief Summary
The purpose of this study is to study the efficacy of allergen injection immunotherapy for allergic rhinitis by
* symptoms score
* medication score
* quality of life
* immunologic test from blood
- Detailed Description
Compare the efficacy of allergen injection immunotherapy between the treatment group and the placebo group after injection for
* 2 months
* 6 months
* 12 months
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 84
- patients with the symptoms of allergic rhinitis who sensitized to mite (Dermatophagoides pteronyssinus)
- positive skin prick test to D.p. at 4+ degree
- steroid dependent asthma
- force expiratory volume (FEV1) less than 70% of predicted value
- previous injection immunotherapy within 2 years
- pregnancy
- medical conditions such as ischemic heart disease, autoimmune disease, cancer, previous history of anaphylaxis
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Total nasal symptoms score average within 1 week 3 point scale (0,1,2,3) and combination of
* nasal block
* rhinorrhea
* itching
* sneezing
- Secondary Outcome Measures
Name Time Method Combined total symptoms score and medication score average within 1 week Total symptom score (nasal block, rhinorrhea, itching, sneezing, and eye symptoms with chest symptoms = Maximal score --\> 18 devided by 6 = 3) PLUS medication score ( antihistamine = 1, topical nasal steroid = 2; --\> Maximal score = 3).
Trial Locations
- Locations (1)
Division of Allergy and Rhinology, Faculty of Medicine Siriraj, Mahidol University
🇹🇭Bangkok, Thailand
Division of Allergy and Rhinology, Faculty of Medicine Siriraj, Mahidol University🇹🇭Bangkok, Thailand