Children's Health in London and Luton (CHILL)
- Conditions
- Child DevelopmentPollution; ExposureRespiratory Disease
- Interventions
- Other: Ultra Low Emission Zone (ULEZ)
- Registration Number
- NCT04695093
- Lead Sponsor
- Queen Mary University of London
- Brief Summary
Investigating the impact of London's Ultra Low Emission Zone on children's respiratory health
- Detailed Description
Strong evidence links urban air pollution to restrictions in children's lung growth and development and other adverse effects, including increases in respiratory and allergy symptoms, respiratory infections, asthma, and health care use. Effective interventions are urgently needed that reduce air pollution and improve child health. Low Emission Zones (LEZ) are becoming widespread but are expensive to implement and of unproven health benefit. London has some of the worst air pollution in Europe. London's Ultra Low Emission Zone (ULEZ) is the central component of London's air quality strategy. Its implementation provides a unique opportunity to test the impact of a city-wide LEZ on children's health.
The intervention:
The ULEZ is an area within which all vehicles must meet exhaust emission standards or pay a daily charge to travel. It will be implemented and paid for by Transport for London. Starting in 2019, the ULEZ will initially cover London's central Congestion Charging Zone, an area bounded by the London Inner Ring Road, that includes the City of London plus adjacent areas of eight radially adjoining Boroughs. It is projected to deliver for central London by 2020 emission reductions of -49% for NOx; - 47% for NO2; and -11% for PM10. Subject to consultation, the ULEZ will subsequently extend to include an inner London area (within London's North and South Circular roads), and a London-wide area, for heavy vehicles only.
Questions:
1. What is the impact of the ULEZ on children's lung growth (the primary outcome)?
2. What is the impact of the ULEZ on secondary outcomes, including self-reported symptoms, respiratory infection, health care use and costs?
3. Does the ULEZ reduce health inequalities? 4) Is the ULEZ good value for money?
Study design:
Quasi-experimental study using a parallel cohort design. Population: 1520 children aged 6-9 yrs old, recruited in 26 London primary schools (school years 2, 3 and 4) in London's Central Ultra Low Emission Zone. Intervention: Ultra Low Emission Zone Comparison: 1520 children aged 6-9 yrs old, recruited in 26 primary schools (school years 2, 3 and 4) in Luton, matched for ethnicity, deprivation and baseline air quality.
Outcome: PRIMARY: Lung function growth (post-bronchodilator forced expiratory volume in one second (FEV1) measured by high quality spirometry at sequential annual school visits over four years. SECONDARY: Forced vital capacity (FVC), exhaled nitric oxide (FeNO), quality of life, respiratory infections, health care use, health costs.
Sample size:
To detect a 15ml/year FEV1 difference between central and outer London cohorts at 90% power and 0.05 significance requires children in each cohort, inflated to allow for clustering effect of schools, spirometry success, child and school attrition, and pre-specified sub group analyses, giving a total of 3120 children (60 children from 26 schools in each cohort).
Duration: 6 years Air quality data: Modeled exposures by London Air Quality Network Data management: NIHR accredited Pragmatic Clinical Trials Unit Analysis: Interaction analysis controlling for effect modifiers (eg passive smoke; ethnicity); health economic cost consequence analysis.
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 3312
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Inclusion criteria for schools:
- Primary schools within, or with catchment areas that include, the Central London ULEZ.
- Primary schools within the Borough of Luton and town of Dunstable.
- State or independent sectors.
Inclusion criteria for children:
• Children attending a study school, in years 2, 3, or 4, at study inception.
-
Exclusion criteria for schools:
- Schools that are not primary schools within the above boundaries.
Exclusion criteria for children:
- Children with learning or physical disabilities sufficient for them to be unable to give informed assent to the study, or to carry out study procedures.
- Children with major lung disease (not including asthma).
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description London (intervention) Ultra Low Emission Zone (ULEZ) 1606 children aged 6-9 yrs old, recruited in 44 London primary schools (years 2-4) within the Central London ULEZ area
- Primary Outcome Measures
Name Time Method Lung function growth as change in forced expiratory volume in one second (FEV1) per year Four years, 2018 -2021 Measured by annual spirometry, as annual change in FEV1/year over 4 years
- Secondary Outcome Measures
Name Time Method Air quality, nitrogen dioxide (NO2) concentration derived from the the KCLUrban dispersion model Four years, 2018 -2021 Annual nitrogen dioxide (NO2) concentration (micrograms/cubic meter NO2)
Annual prevalence of wheeze, as proportion (%) of respondents reporting wheeze Four years, 2018 -2021 International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire for 6-7 year olds
Annual prevalence/participant of upper respiratory tract infections Four years, 2018 -2021 Electronic download of coded NHS health record data
Annual prevalence/participant of lower respiratory tract infections Four years, 2018 -2021 Electronic download of coded NHS health record data
Annual health care use per participant Four years, 2018 -2021 Electronic download of coded NHS health record data
Child Quality of Life as score out of 40 Four years, 2018 -2021 Annual parental completion of the CHU9D (Child Health Utility 9 Dimension) questionnaire
Air quality, oxides of nitrogen (NOx) concentration derived from the KCLUrban dispersion model Four years, 2018 -2021 Annual oxides of nitrogen (NOx) concentration (micrograms/cubic meter NOx)
Lung capacity as FVC (forced vital capacity) Four years, 2018 -2021 Measured by annual spirometry, as FVC in litres
Air quality, particulate matter diameter <2.5microns derived from the KCLUrban dispersion model Four years, 2018 -2021 Annual particulate matter diameter \<2.5microns (PM2.5) concentration (micrograms/cubic meter PM10)
Annual prevalence of rhinitis, as proportion (%) of respondents reporting rhinitis Four years, 2018 -2021 International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire for 6-7 year olds
Cognitive function as average Movement Time in seconds (MT) on the Clinical Kinematic Assessment Test Three years, 2019 -2021 Annual Clinical Kinematic Assessment Test
Annual prevalence of eczema, as proportion (%) of respondents reporting eczema Four years, 2018 -2021 International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire for 6-7 year olds
Annual health care costs per participant Four years, 2018 -2021 Electronic download of coded NHS health record data and self report data
Physical activity, as Percentage time in Moderate to Vigorous Physical activity per participant (MVPA) Four years, 2018 -2021 Annual hip accelerometer records of participants, measured over one week
Trial Locations
- Locations (1)
Queen Mary University of London
🇬🇧London, United Kingdom