Weissella Cibaria JW15 Consumption and NK Cell Activity
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Yonsei University
- Enrollment
- 100
- Primary Endpoint
- Natural killer cell activity at 8-week follow up
Study Overview
Brief Summary
A The aim of this study was to investigate the impact of consuming Weissella cibaria (W. cibaria) JW15 supplementation isolated from Kimchi, Korea traditional fermented food, on natural killer (NK) cell activity and circulating levels of cytokines and immunoglobulin (Ig).
Detailed Description
A randomized, double-blinded, placebo-controlled study was conducted on 100 nondiabetic subjects. Over an eight-week testing period, the probiotic group consumed 4 capsules (300 mg/capsule) containing 1 x 10^10 colony-forming units (cfu) of W. cibaria JW15 each day, whereas the placebo group consumed the same product without a probiotic.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Supportive Care
- Masking
- Double (Participant, Investigator)
Eligibility Criteria
- Ages
- 20 Years to 70 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Nondiabetic (fasting serum glucose concentration < 126 mg/dL)
- •Subjects with 4,000-8,000 leukocyte counts
Exclusion Criteria
- •Constant consumption of any probiotic products
- •Taking medicine related to inflammation within one month before screening
- •Allergy to probiotics
- •Lactose intolerance
- •History/presence of significant metabolic disease
- •Acute or chronic disease requiring treatment
- •Taking any medications
Outcomes
Primary Outcomes
Natural killer cell activity at 8-week follow up
Time Frame: 8-week follow up
Natural killer cell activity (%)
Natural killer cell activity at baseline
Time Frame: Baseline
Natural killer cell activity (%)
Secondary Outcomes
No secondary outcomes reported
Investigators
Jong Ho Lee
Professor
Yonsei University