Weissella Cibaria JW15 Consumption and NK Cell Activity

Not Applicable

Completed

• Conditions: Immune Function
• Interventions: Dietary Supplement: Placebo; Dietary Supplement: Probiotic

• Registration Number: NCT03209635
• Lead Sponsor: Yonsei University

Brief Summary

A The aim of this study was to investigate the impact of consuming Weissella cibaria (W. cibaria) JW15 supplementation isolated from Kimchi, Korea traditional fermented food, on natural killer (NK) cell activity and circulating levels of cytokines and immunoglobulin (Ig).

Detailed Description

A randomized, double-blinded, placebo-controlled study was conducted on 100 nondiabetic subjects. Over an eight-week testing period, the probiotic group consumed 4 capsules (300 mg/capsule) containing 1 x 10\^10 colony-forming units (cfu) of W. cibaria JW15 each day, whereas the placebo group consumed the same product without a probiotic.

Study Timeline

• Study Start: 2016-04-01
• Primary Completion: 2017-03-20
• Study Completion: 2017-03-20
• Status Verified: 2017-07
• Study First Submitted: 2017-07-04
• Study First Submitted QC: 2017-07-04
• Last Update Submitted: 2017-07-04
• Study First Posted: 2017-07-06
• Last Update Posted: 2017-07-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Nondiabetic (fasting serum glucose concentration < 126 mg/dL)
• Subjects with 4,000-8,000 leukocyte counts

Read More

Exclusion Criteria

• Constant consumption of any probiotic products
• Taking medicine related to inflammation within one month before screening
• Allergy to probiotics
• Lactose intolerance
• Diabetes
• History/presence of significant metabolic disease
• Acute or chronic disease requiring treatment
• Taking any medications

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Placebo	Placebo	4 capsules (300 mg/capsule) containing 52% crystalline cellulose and 46% lactose in identical-looking with test product
Probiotic	Probiotic	4 capsules (300 mg/capsule) containing each capsule 1.0 x 10\^10 colony-forming units (cfu) of Weissella cibaria JW15, twice a day

Primary Outcome Measures

Name	Time	Method
Natural killer cell activity at 8-week follow up	8-week follow up	Natural killer cell activity (%)
Natural killer cell activity at baseline	Baseline	Natural killer cell activity (%)