MAEPLE study
- Conditions
- epilepsy
- Registration Number
- JPRN-jRCTs031180070
- Lead Sponsor
- Miyazaki Tomoyuki
- Brief Summary
The primary endpoint of the study showed that there were regions of higher AMPA receptor density in PVC processed images compared to healthy subjects in both the partial and generalized seizure groups. On the other hand, no significant trend was observed in the images without PVC treatment. We also investigated the areas where EEG activity correlated with AMPA receptors and FDG-PET imaging values, as well as the areas where IQ correlated with AMPA receptors and FDG-PET imaging values. In addition, there wer
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Male
- Target Recruitment
- 34
1. Patients diagnosed with epilepsy on the basis of ILAE criteria
2. Patients who have seizures 12months prior to registration
3. Patients without neurosurgery in the past
4. Patients who are over 20 years and below 60 years
5. Patients who can consent to this study by oneself
1. Patients who have experienced the electric stimulation therapy
2. Patients who have severe renal dysfunction (Serum Cre>1.5)
3. Patients who have severe liver dysfunction (AST and ALT>150)
4. Patients who have severe cardiovascular disorder
5. Patients who have tatoo
6. Claustrophobic patients
7. Patients who can not agree with contraception during 7days after [11C]K-2 PET
8. Patients who take Perampanel or Topiramate(within 1month before this registration)
9.Patients who underwent nuclear medicine examination within
1 week before this registration
10.Patients who underwent other clinical trials using unapproved
nuclear medicine examination within 6 months before this
registration
11.Patients who underwent other clinical trial within 12 weeks before this registration
12.Patients whom study doctors consider inappropriate
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.