AMPA receptors PET imaging in stroke-aphasia patients
- Conditions
- Stroke, aphasia
- Registration Number
- JPRN-jRCTs031200289
- Lead Sponsor
- Abe Hiroki
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 8
1. 20 years older and 86 years younger at the registration
2. Diagnosed as initial symptomatic stroke with aphasia
3. A Patient who can express his or her intent to participate in this research with written documents by himself or herself. When a patient is unable to write his or her sign due to their aphasia symptom, a substitute who was asked to write his or her sign by the patient can express intents to participate in this research with written documents in stead of the patient.
1. Patients with Raven's coloured porgressive Matrices's score less than 18
2. Patients with Brunstrome stage less than 4 in at least one area among fingers, upper limbs and lower limbs
3. Patients with biochemical examination below ; (a) serum Cr >=2.0 mg/dl, (b) AST >=200 IU/L, (c) ALT >=150 IU/L
4. Patients with post-stroke epilepsy
5. Patients who need an administrarion of perampanel
6. Patients with dialysis
7. Patients who can not undergo head 3T-MRI
8. Patients who desire to undergo non invasive brain stimulation therapy
Study & Design
- Study Type
- Other
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes of WAB scores during 8 weeks-speech therapy and delta %SUV of [11C]K-2 in language related areas (LanA) and its homologous areas (HomA). In this study, LanRA reffers to precentralgyrus, supramarginal gyrus, angular gyrus, superior and middle temporal gyrus, posterior inferior temporal gyrus and inferior frontal gyrus in lesional hemisphere, while HomA reffers to those in contra-lesional hemisphere.
- Secondary Outcome Measures
Name Time Method