Efficay comparison two oral chelators combination in patients with beta-thalassemia
Not Applicable
Recruiting
- Conditions
- Two oral chelattor consumption in patients with beta thalassemia.
- Registration Number
- IRCT20160310026998N7
- Lead Sponsor
- Tabriz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 54
Inclusion Criteria
ß thalassemia patients who have continuous blood transfusions receiving deferoxamine with deferiprone.
Exclusion Criteria
Patients who changes their chelator during the study.
Patients who changes thier blood transfusion pattern during the study
Patients with liver complications (rise of aminotransferase >5 times of baseline)
Pregnant women
Patients with renal insufficiency with a creatinine clearance (GFR) of less than 30 ml / min.
patients with renal adverese effect of chelating agent (rise serum creatinine>2 time of baseline orproteinuria)
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Ferritine level. Timepoint: baseline and after 6 months. Method of measurement: blood sample.;Quality of life. Timepoint: baseline and after 6 months. Method of measurement: Questionare.;MRI indinces. Timepoint: baseline and after 6 months. Method of measurement: MRI.
- Secondary Outcome Measures
Name Time Method