跳至主要内容
临床试验/NCT03338179
NCT03338179已完成不适用

Evaluation of Metamemory in Patients With Schizophrenia

University Hospital, Clermont-Ferrand1 个研究点 分布在 1 个国家目标入组 120 人开始时间: 2011年2月8日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
120
试验地点
1
主要终点
difference of judgement of learning using a 5 point scale (0%, 25%, 50%, 75%, 100%) using a generation strategy.

研究概览

简要总结

The purpose of this study is to determine the respective roles of aging and schizophrenia in the regulation of metamemory using a generation strategy. 4 groups will be necessary to comparison:

Adult patients (18-45 years) Adult controls (18-45 years) Aged patients (≥ 59.5 years) Aged controls (≥ 59.5 years)

The effects of age and the disease could lead to interaction in regulating metamemory. The effect of age would be aggravated by the disease.

详细描述

Metamemory measurement

  • Objective: Measurement of monitoring and control capabilities, and relations between these two abilities when learning of word pairs.
  • Description: The hardware consists of two lists of 30 pairs of French words, each pair of words being composed of a word index and a target word (names of concrete objects). Among the 60 word pairs, 30 are strongly associated items (or easy items, the other 30 being weakly associated or difficult items.

In front of a computer screen, each participant is subjected to a learning test in which 30 pairs of words appear one by one on the screen. Participants have the option to control the time of presentation of each pair of words. After a retention time of 4 minutes of information devoted to nonverbal distractive task, follows an evaluation phase of deferred judgments of learning (JOL time), where for each pair of words studied, the word index is presented without the target word. Participants must then assess a learning judgment for each pair of words, that is to say they have to estimate, on a 5-point scale, their ability to remember later the target word in the presentation the index word. This JOL assessment phase is immediately followed by cued recall test.

For the second learning test (30 other word pair), the steps are identical. Prior to this second learning, generating instruction of a pair of words to learn is proposed: a word index is presented to the participants who have to generate a pair with a target word. Participants are trained on 5 pairs of words.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Basic Science
盲法
None

盲法说明

no masking

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者
是

入选标准

  • •For both:
  • •Age: between 18 and 45 years for adults, and 59.55 and above for older,
  • •For patients :
  • •DSM-5 criteria of schizophrenia
  • •Adult patients (<45 years) will be matched to elderly patients (> 59.55 years) gender and educational level,
  • •Patients followed as outpatients,
  • •Age of onset of the disease less than 40 years,
  • •Patients whose disease has stabilized: no changes psychotropic treatment for at least 1 month
  • •Not more of a benzodiazepine,
  • •Patients on protection of justice or not,
  • •For controls :
  • •- Matched for sex to patient
  • •Age-matched (+/- 3 years) to patient
  • •Matched for educational level (+/- 2 years) to patients

排除标准

  • •-For patients :
  • •Any other comorbid psychiatric diagnosis of Axis I DSM-5 (particularly depression, addiction excluding tobacco, dementia)
  • •Patients with impaired vision or hearing preventing the realization of the tests.
  • •Long-term Anticholinergic treatment.
  • •Patients with less 5 years of school
  • •For controls:
  • •Any psychiatric diagnosis according to DSM-5, including addictions (excluding tobacco)
  • •Head injuries, brain injuries or diseases,
  • •vision or hearing problems preventing the realization of the tests.
  • •Current or past addiction to all toxic substances except tobacco.
  • •Long-term Anticholinergic treatment.
  • •Related to the first degree diagnosed with a psychotic disorder

研究组 & 干预措施

Adult Patients

Experimental

Schizophrenia patients aged between 18 and 45 years old

干预措施: Judgement of learning evaluation (Behavioral)

Aged Patients

Experimental

Schizophrenia patients aged 59.5 years and above

干预措施: Judgement of learning evaluation (Behavioral)

Adult Controls

Active Comparator

Controls aged between 18 and 45 years old

干预措施: Judgement of learning evaluation (Behavioral)

Aged Controls

Active Comparator

Controls aged 59.5 years and above

干预措施: Judgement of learning evaluation (Behavioral)

结局指标

主要结局

difference of judgement of learning using a 5 point scale (0%, 25%, 50%, 75%, 100%) using a generation strategy.

时间窗: at day 1

the 4 groups of participants formed by the case-control study in two age strata value their judgments of learning for each pair of words using a 5 point scale (0%, 25%, 50%, 75%, 100%) with the generation strategy.

次要结局

  • Difference of number of recalled word using a generation strategy(at day 1)
  • Difference of number of recalled word between generation and reading strategies(at day 1)
  • Difference of judgement of learning using a 5 point scale (0%, 25%, 50%, 75%, 100%) between generation and reading strategies(at day 1)

研究者

发起方
University Hospital, Clermont-Ferrand
申办方类型
Other
责任方
Sponsor

研究点 (1)

Loading locations...

相似试验

Evaluation of Metamemory in Patients With... | 临床试验