Deep rTMS in Parkinson Disease Pain Syndromes
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Pain
- Sponsor
- University of Sao Paulo
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Change in baseline of Pain
- Last Updated
- 7 years ago
Overview
Brief Summary
Pain is the most prevalent non-motor symptom in Parkinson disease, and the motor improvement not always is related to the pain improvement with the medication treatment. By this, we are testing a non-invasive method called transcranial magnetic stimulation as an alternative to treat pain related to Parkinson disease. This technique can lead to either inhibitory or excitatory effects in brain circuits depending on stimulation parameters, and is known to provide analgesic effects.
Investigators
Daniel Ciampi Araujo de Andrade, MD, PhD
MD, PhD (Head of Pain Division)
University of Sao Paulo
Eligibility Criteria
Inclusion Criteria
- •Parkinson disease
- •Signed term of informed consent
- •Parkinsson disease related pain
Exclusion Criteria
- •Trauma of Skull, epilepsy don't treated
- •Use of medications decrease the seizure threshold
- •Patients in use of drugs, how cocaine and alcohol
- •neurosurgical clips, pacemakers, increased intracranial pressure (risk of sequelae after seizure)
- •Pregnant or lacting women
- •Moderate or severe cognitive impairment
Outcomes
Primary Outcomes
Change in baseline of Pain
Time Frame: base line (moment of inclusion), day 15th, day 45th and in the last day of the sessions of rTMS (4X in two months)
assessing by Visual Analog Scale for Pain (VAS). This scale range from 0 (no pain) to 10 (maximum pain), being considered an effective improvement in the patient's pain when the pain decreases at least in 30% from the basal score.