Combining Motor Imagery and Tendon Vibration on the Effectiveness of Motor Imagery

Not Applicable

Not yet recruiting

• Conditions: Healthy Volunteer

• Registration Number: NCT06845176
• Lead Sponsor: Centre Hospitalier Universitaire de Saint Etienne

Brief Summary

Kinesthetic motor imagery (kMI) involves imagining the sensations of movement, activating brain regions similar to actual movement execution. It is widely used to maintain or restore motor functions, particularly in rehabilitation. Tendon vibration (TV), which stimulates proprioceptive receptors can also enhance corticospinal excitability and promote neuroplasticity. This project investigates the coupling of kMI and TV through three modalities: simultaneous application, TV application between kMI trials, or pre-application of TV to precondition the nervous system before kMI trials. The effectiveness and quality of kMI will be assessed by corticospinal excitability measurements using transcranial magnetic stimulation and EEG measures. Conducting this study in healthy participants will inform the development of optimized clinical interventions for immobilized or mobility-reduced patients.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-02
• Study First Submitted: 2025-02-20
• Study First Submitted QC: 2025-02-20
• Last Update Submitted: 2025-02-20
• Study First Posted: 2025-02-25
• Last Update Posted: 2025-02-25
• Study Start: 2025-03-11
• Primary Completion: 2027-03-01
• Study Completion: 2027-03-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 33

Inclusion Criteria

• Men or women aged 18 to 50 years.
• Affiliated with or beneficiaries of a social security system.
• Provided written informed consent freely after being informed of the study's purpose, procedures, and potential risks.

Exclusion Criteria

• History of pathology or surgery affecting upper limb motor function within 6 months prior to the study.
• Chronic neurological, motor, or psychiatric disorders.
• Use of neuroactive substances likely to alter corticospinal excitability (e.g., hypnotics, antiepileptics, psychotropics, muscle relaxants) during the study period.
• Contraindications to transcranial magnetic stimulation
• Simultaneous participation in another interventional study or participation in such a study within 30 days prior to this study.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Optimization of kMI	30 minutes	We will measure corticospinal excitability. This will be assessed by the area (in mV.%) under the curve representing the amplitude of motor-evoked potentials (MEPs, in mV) recorded via electromyography, as a function of transcranial magnetic stimulation intensity (in % of the stimulator's maximal output) required to evoke these potentials.

Trial Locations

Locations (1)

IRMIS-Hôpital Nord; 🇫🇷 Saint-etienne, France