Thiol/Disulphide Homeostasis and Vascular Endothelial Growth Factor Levels in Diabetic Children

Completed

• Conditions: Periodontal Diseases
• Interventions: Diagnostic Test: ELISA

• Registration Number: NCT04470635
• Lead Sponsor: Aydin Adnan Menderes University

Brief Summary

The aim of this study to evaluate the vascular endothelial growth factor level and thiol/disulphide homeostasis in saliva of diabetic children with gingivitis.

Detailed Description

Eighty children (44 with type 1 diabetes mellitus and 44 systemically healthy) will be recruited for the study. The children will be divided into four subgroups based on their periodontal and systemic condition: 1) systemically and periodontally healthy children, 2) systemically healthy children with gingivitis, 3) periodontally healthy children with T1DM, and 4) children with T1DM and gingivitis. The plaque index, gingival index, probing pocket depth, will recorded. The vascular endothelial growth factor level determined by ELISA. Native thiol, total thiol and disulphide levels will be measured in saliva.

Study Timeline

• Study First Submitted: 2020-07-10
• Study First Submitted QC: 2020-07-10
• Study First Posted: 2020-07-14
• Study Start: 2020-07-25
• Primary Completion: 2020-09-30
• Study Completion: 2020-10-01
• Status Verified: 2024-01
• Last Update Submitted: 2024-01-29
• Last Update Posted: 2024-01-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Children diagnosed as type 1 diabetes mellitus
• Age between 7-14 years

Exclusion Criteria

• Having another systemic problem except type 1 diabetes mellitus
• Children carrying orthodontic appliances

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Healthy children and healthy gingiva	ELISA	Systemically healthy children with healthy gingiva
Type 1 diabetes with healthy gingiva	ELISA	Children with type 1 diabetes mellitus and healthy gingiva
Type 1 diabetes with gingivitis	ELISA	Children with type 1 diabetes mellitus and gingivitis
Healthy children with gingivitis	ELISA	Systemically healthy children with gingivitis

Primary Outcome Measures

Name	Time	Method
Vascular endothelial growth factor level	Baseline	Vascular endothelial growth factor level in saliva

Secondary Outcome Measures

Name	Time	Method
Thiol/disulphide measurement	Baseline	Total thiol, native thiol and disulphite level in saliva

Trial Locations

Locations (1)

Sultan Keles; 🇹🇷 Aydın, Turkey