Calcium Retention as Influenced by Dietary Components That Induce an Acid Load
- Conditions
- Healthy
- Registration Number
- NCT00620763
- Lead Sponsor
- USDA Grand Forks Human Nutrition Research Center
- Brief Summary
The impact of protein sources such as beef as part of Western diet on calcium retention remains controversial. We propose to test the hypothesis that the positive effect of high protein intake (especially from meat protein) can offset the negative effect of protein-induced net acid load on bone metabolism and the retention of body calcium. Healthy postmenopausal women recruited from the community will consume two diets differing in meat protein and acid load for 7 weeks. Calcium retention from diets will be determined using a highly sensitive measurement of whole body retention of a calcium isotope added to the diet.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 22
- Average body mass index
- Normal blood work
- Normal bone density
- Chronic disorder
- Non-traumatic bone fractures
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Calcium Absorption 18 weeks After 3 weeks equilibration to the diet, the 2-day menu was extrinsically labeled with Calcium-47 radiotracer and retention was monitored for 28 days by whole body scintillation counting. Percent Calcium-47 absorbed was estimated from the y-intercept of the linear portion of a semilogarithmic plot of percent Calcium-47 retained vs time.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
United States Department of Agriculture (USDA) Grand Forks Human Nutrition Research Center
🇺🇸Grand Forks, North Dakota, United States
United States Department of Agriculture (USDA) Grand Forks Human Nutrition Research Center🇺🇸Grand Forks, North Dakota, United States