TCTR20200824001招募中4 期
Pharmacologic profile of direct oral anticoagulants in patients receiving Rituximab-CHOP chemotherapy
适应症
试验速览
- 阶段
- 4 期
- 状态
- 招募中
- 入组人数
- 26
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 Years 至 0 N/A (No limit)（—）
- 性别
- All
入选标准
- •1.Provided informed consent
- •2.Age ≥ 18 years
- •3.Body mass index (BMI) of 18.5-29.9 kg/m2
- •4.Newly diagnosed non-Hodgkin lymphoma, diffuse large B-cell lymphoma subtype, and who are planned to be treat with R-CHOP chemotherapy regimen
- •5.Khorana score of 2 or higher
排除标准
- •1.Patients who are known to have significant liver disease or dysfunction (AST or ALT > 3 times ULN, Total bilirubin greater than > 2 times ULN). Examples of significant liver disease include acute clinical hepatitis, chronic active hepatitis, or cirrhosis
- •2.Patients who have severe renal impairment, defined as calculated creatinine clearance (CrCl) less than 30 mL/min
- •3.Patients who have significant respiratory, cardiovascular, metabolic, endocrine or neurologic disorders
- •4.Patients who have uncorrected mucosal lesions
- •5.Patients who have central nervous system involvement of lymphoma
- •6.Patients who have high disease burden, tumor lysis syndrome or those who require emergency radiation therapy
- •7.Patients who have poor performance status, evaluated by the Eastern Cooperative Oncology Group (ECOG) performance status equal or greater than 3
- •8.Patients who recently have surgery within 30 days of the enrollment
- •9.Patients who recently have major bleeding within 90 days of the enrollment
- •10.Patients with history of intracranial bleeding
- •11.Patients who concurrently treated with anticoagulants (LMWH, DOAC or warfarin) or antiplatelets
- •12.Patients who are pregnant or lactating
研究者
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