Clinical Significance of 64-slice Multidetector Coronary CT Angiography to Evaluate the Prevalence and Severity of Coronary Artery Disease in Renal Transplant Recipients

Not Applicable

Completed

• Conditions: Kidney Transplant Recipient
• Interventions: Other: 64-slice Multidetector coronary CT angiography

• Registration Number: NCT01753505
• Lead Sponsor: Yonsei University

Brief Summary

The aim of this study is to evaluate the clinical usefulness of 64-slice multidetector coronary CT angiography (MDCTA) in renal transplant recipients who had no previous coronary artery disease (CAD). Primary endpoint is to assess the prevalence and severity of coronary artery disease in patients post-transplant 6 to 12 months. CAD can be diagnosed noninvasively with similar accuracy of coronary angiography using MDCTA. Early detection and intervention of CAD may provide survival benefit in renal transplant recipients.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2012-12-17
• Study First Submitted QC: 2012-12-17
• Study First Posted: 2012-12-20
• Study Start: 2013-02-01
• Primary Completion: 2014-07-28
• Study Completion: 2014-07-28
• Status Verified: 2017-11
• Last Update Submitted: 2017-11-26
• Last Update Posted: 2017-11-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 93

Inclusion Criteria

1. age ≥ 40 yrs
2. renal transplant recipient at post-transplant 6 to 12 months
3. stable graft renal function: CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equation ≥45 mL/min/1.75m2
4. patients who had no previous CAD

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Exclusion Criteria

1. unstable graft renal function
2. History of acute kidney injury within 3 months
3. Allergic history to contrast agent
4. Irregular heart beat
5. Multiorgan transplant recipients
6. Pregnancy
7. Patients who do not consent to this study

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
MDCTA	64-slice Multidetector coronary CT angiography	-

Primary Outcome Measures

Name	Time	Method
prevalence of coronary artery disease	at post-transplant 6 to 12 months.

Secondary Outcome Measures

Name	Time	Method
severity of coronary artery disease	at post-transplant 6 to 12 months

Trial Locations

Locations (1)

Severance hospital; 🇰🇷 Seoul, Korea, Republic of