Efficacy of multimodal analgesia before and after impacted mandibular third molar surgery

Not Applicable

Completed

Conditions: Diseases of the digestive system

Registration Number: KCT0005450

Lead Sponsor: Chungnam National University Hospital

Brief Summary: <Efficacy Results> - In Group A, experimental drug significantly reduces pain at 3 and 6 hours after tooth extraction compared to taking a placebo, and also lowers the intensity of the initial perceived pain. - In Group B, experimental drug significantly reduces pain at 1 and 6 hours after tooth extraction compared to taking a placebo, and delays the onset of initial perceived pain. - There is no significant association between the use of experimental drugs and the need for additional analgesics within 12 hours post-surgery in both group A and B. <Safety Results> - There is no significant association between the use of experimental drugs in both group A and B, and the occurrence of adverse reactions (drug-related side effects). - No other abnormal cases were observed in vital signs, physical examinations, or medical procedures.

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 66

Inclusion Criteria

Healthy adult males and females without systemic diseases aged 19 to 40 years old
-Those who have no abnormal findings on blood tests (CBC, aPTT, PT) conducted within the last 3 weeks
-When the impaction of both mandibular third molars is confirmed
-On panoramic radiographs, more than 1/3 of the crown is covered with the alveolar bone and need to be surgically extracted.
(including both gingival incision, tooth separation, bone removal)
-A person who fully understands and agrees with the purpose of the research and voluntarily permits participation in the research

Exclusion Criteria

- Have a history of allergy on drugs used in this study
(Celecoxib, tramadol, acetaminophen, cefaclor, zaltoprofen, rebamipide)
-If there is pericoronitis or benign lesions on the impacted mandibular third molars
- If you need to take the analgesic drugs continuously until the time of extraction and maintains analgesic effect
-Pregnant or lactating person
-Smokers and others who are judged to be inappropriate to participate in clinical trials