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临床试验/NCT07482800
NCT07482800招募中不适用

Examining Representations of Dementia in Fiction and Clinical Narratives

Fu Jen Catholic University1 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2026年3月17日最近更新:
适应症

试验速览

阶段
不适用
状态
招募中
入组人数
40
试验地点
1
主要终点
Mini-Mental State Examination

研究概览

简要总结

This study aims to compare the natural narrative language of patients with Alzheimer's disease and the fictional depictions of dementia in contemporary novels from both neurological and literary perspectives. It investigates the similarities and differences in the deterioration of semantic and episodic memory. The goal is to develop a cross-disciplinary language observation model that enhances early diagnostic understanding, fosters empathy in caregiving, and strengthens medical humanities education.

详细描述

Background: Dementia is a major neurodegenerative disease of concern in aging societies worldwide, with Alzheimer's disease being the most common form. Early symptoms often involve language impairments and narrative disorganization. While neurology has extensively studied semantic memory and pragmatic dysfunction, systematic analysis of natural language narratives remains limited. Meanwhile, contemporary "neuronovels" depict the linguistic and cognitive decline of characters with dementia in highly realistic and emotionally resonant ways, providing narrative insights that may complement clinical observations. This project uses novels such as The Tunnel by A. B. Yehoshua and Still Alice by Lisa Genova as key texts, integrating real patient data and neurobehavioral assessments to construct a model that bridges clinical and literary approaches.

Study Design: This is a one-year prospective study.

Methods: Semi-structured interviews will be conducted to collect spontaneous narratives focusing on childhood memories, life events, and self-description. Audio recordings will be transcribed and analyzed for linguistic features and behaviors. In parallel, fictional narratives from selected dementia-themed novels will be analyzed for language disruption, narrative fragmentation, and identity construction in characters with dementia. A multidisciplinary team will conduct cross-comparative analyses between clinical data and literary texts to establish a reference framework of language decline and narrative behavior for future diagnostic support and empathy training.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Prospective

入排标准

年龄范围
60 Years 至 85 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Diagnosed with early-stage Alzheimer's disease or other mild cognitive impairment by a neurologist (case group) / healthy individuals matched for age and education level (control group)
  • Able to communicate and understand basic language

排除标准

  • Refuse to participate in the study

研究组 & 干预措施

Case group

Diagnosed with early-stage Alzheimer's disease or other mild cognitive impairment by a neurologist

Control group

Healthy individuals matched for age and education level

结局指标

主要结局

Mini-Mental State Examination

时间窗: on the day of enrollment

assess cognitive function, including orientation, memory, attention, language, and basic visuospatial ability

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Ke-Yun, Chao

Assistant Professor

Fu Jen Catholic University

研究点 (1)

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Dementia in Fiction and Clinical Narratives | 临床试验