NCT04234295已完成不适用
Investigating the Effect of Obesity on Eosinophil Recruitment in Human Adipose Tissue
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Mayo Clinic
- 入组人数
- 24
- 试验地点
- 2
- 主要终点
- Number of eosinophils in adipose tissue
研究概览
简要总结
Researchers are trying to better understand the relationship between inflammation in adipose tissue (AT) and insulin resistance.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adults ages 30-50 years
- •Non-smokers
- •Lean subjects with a BMI of 25 or less, gender specific normal body fat,
- •Obese, non-diabetic subjects with a BMI between 30 and 50 and taking no medications affecting glucose metabolism or lipid metabolism
- •subjects scheduled for an elective laparoscopic or laparotomy abdominal surgery
排除标准
- •Receiving corticosteroid therapy or have a history of asthma, COPD or atopic syndrome
- •taking any biologic treatment for any autoimmune disorder
- •Taking any leukotriene receptor antagonist acting medications (ex. Montelukast)
结局指标
主要结局
Number of eosinophils in adipose tissue
时间窗: baseline
eosinophil number will be measured by flow cytometry in subcutaneous (superficial) adipose tissue
次要结局
- Correlation between eosinophil content and body mass index (BMI)(baseline)
研究者
Elena Anna (Eleanna) De Filippis, M.D., Ph.D.
Principal Investigator
Mayo Clinic
研究点 (2)
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