Glucose Metabolism After Partial Pancreatectomy

Completed

• Conditions: Pancreatectomy; Hyperglycemia; Diabete Mellitus

• Registration Number: NCT04409171
• Lead Sponsor: Seoul National University Hospital

Brief Summary

This is a single center observational study to assess alteration of glucose metabolism after pancreatectomy.

Detailed Description

Biochemical markers of glucose metabolism including oral glucose tolerance tests, fasting blood glucose, insulin, glucagon and HbA1c were performed on patients receiving pancreatectomy (pancreaticoduodenectomy and distal pancreatectomy). Tests were done preoperatively, postoperatively at 3 months, and at 1 year. The primary endpoints were the incidence and risk factors of new-onset and worsened DM after each type of pancreatectomy.

Study Timeline

• Study Start: 2015-09-01
• Primary Completion: 2018-12-31
• Study Completion: 2020-01-31
• Status Verified: 2020-05
• Study First Submitted: 2020-05-26
• Study First Submitted QC: 2020-05-26
• Last Update Submitted: 2020-05-26
• Study First Posted: 2020-06-01
• Last Update Posted: 2020-06-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 224

Inclusion Criteria

• partial pancreatectomy

Exclusion Criteria

• total pancreatectomy
• incomplete testing
• follow-up loss
• death within 1 year

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
incidence & risk factors of new-onset DM	at 1 year	incidence \& risk factors of new onset DM after pancreatectomy
incidence & risk factors of worsened DM	at 1 year	incidence \& risk factors of worsened DM after pancreatectomy

Secondary Outcome Measures

Name	Time	Method
characteristics of new-onset and worsened DM	1 year	changes of glucose metabolism during study period