NCT00750217Unknown4 期
Transfer From Methadone to Buprenorphine Maintenance Treatment Using Buprenorphine Patches: A Study on Practicability With Patients Maintained With Daily Dosages Between 60mg and 100mg Methadone.
Psychiatric University Hospital, Zurich2 个研究点 分布在 1 个国家目标入组 10 人开始时间: 2008年8月1日最近更新:
适应症
相关药物
试验速览
- 阶段
- 4 期
- 发起方
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- Short Opiate Withdrawal Scale
研究概览
简要总结
Buprenorphine is an important alternative to methadone in the maintenance treatment of heroin addiction. Transfer from methadone to buprenorphine requires a reduction of daily methadone dosage below 30 mg to avoid withdrawal after the first buprenorphine intake. The study hypothesis states that the transfer from a daily methadone dosage between 60 mg and 100 mg to buprenorphine can be carried out without withdrawal using buprenorphine patches (35 micro grams per hour) within 12 to 48 hours after last methadone intake.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age between 18 and 60 years
- •Methadone maintenance treatment for at least 3 months preceding the study
- •Daily methadone dosage between 60mg amd 100mg
- •Sufficient knowledge of German language
- •Ability to give informed consent
排除标准
- •Daily methadone dosage below 60mg amd over 100mg
- •Prescribed use of benzodiazepines over 30 mg equivalent to diazepam
- •Misuse or dependence of alcohol and/or GHB/GBL
- •Pregnant or breast-feeding women
- •Known intolerance of buprenorphine
- •Somatic diseases interfering with the study plan
结局指标
主要结局
Short Opiate Withdrawal Scale
时间窗: 14 days
次要结局
- Heroin use(60 days)
研究者
研究点 (2)
Loading locations...
相似试验
终止
不适用
Effects of Buprenorphine/Naloxone in Treating Opioid Dependent Individuals Who Are Maintained on MethadoneOpioid-Related DisordersNCT00000243National Institute on Drug Abuse (NIDA)16
已完成
2 期
Buprenorphine Maintenance for Opiate Dependence - 6Opioid-Related DisordersSubstance-Related DisordersNCT00000357National Institute on Drug Abuse (NIDA)
已完成
3 期
Buprenorphine Maintenance Protocol - 1Opioid-Related DisordersNCT00000205University of California, Los Angeles
已完成
1 期
Interim Buprenorphine: Leveraging Medication + Technology to Bridge Delays in Treatment AccessOpioid-related DisordersNCT02360007University of Vermont Medical Center70
已完成
2 期
Methadone/Buprenorphine Cross-Over Study - 4Opioid-Related DisordersNCT00000208National Institute on Drug Abuse (NIDA)