Effects of grape seed extract supplement on anthropometric measurements, serum lipids, inflammatory markers and neuropeptide Y in overweight or obese individuals
Phase 2
- Conditions
- obesity.localized adiposity, ObesityE65, E66
- Registration Number
- IRCT2015073015968N3
- Lead Sponsor
- Vice chancellor for research, Shahid Beheshti university of medical sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
Inclusion: Aged 20-50 years; Body mass index above 25 kg/m2
Exclusion criteria include: pregnancy, lactation; Menopause in women; History of liver disease; Kidney disease; Thyroid; Celiac; Diarrhea and Acute infection; Recent surgery; Weight loss diet in 6 months ago; Use of any drugs or supplements related to weight loss; Changes in body weight over three kilograms in 2 months ago; The use of Antioxidants supplementation in 3 months ago and Use of anticoagulants such as Aspirin,Warfarin.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Body mass Index. Timepoint: Before intervention, Six weeks after intervention,Twelve weeks after intervention. Method of measurement: calculating.;Weight. Timepoint: Before intervention, six weeks after intervention,Twelve weeks after intervention. Method of measurement: Seca scale.;Waist circumference. Timepoint: Before intervention, six weeks after intervention,Twelve weeks after intervention. Method of measurement: Meter.;Hip circumference. Timepoint: Before intervention, six weeks after intervention,Twelve weeks after intervention. Method of measurement: Meter.;Waist circumference to hip ratio. Timepoint: Before intervention, six weeks after intervention,Twelve weeks after intervention. Method of measurement: Calculating.;Body fat percentage. Timepoint: Before intervention, six weeks after intervention,Twelve weeks after intervention. Method of measurement: Bioelectrical Impedance Analysis.
- Secondary Outcome Measures
Name Time Method Hs-CRP concentration. Timepoint: Before intervent, twelve weeks after intervention. Method of measurement: Enzymatic method by kit.;Serum TNF-alpha concentration. Timepoint: Before intervent, twelve weeks after intervention. Method of measurement: Enzymatic method by kit.;Serum lipids concentration. Timepoint: Before intervent, twelve weeks after intervention. Method of measurement: Enzymatic method by kit.;NPY concentration. Timepoint: Before intervent, twelve weeks after intervention. Method of measurement: Enzymatic method by kit.