Timing of Human Chorionic Gonadotropin Administration in Intrauterine Insemination Cycles
试验速览
- 阶段
- 4 期
- 发起方
- 入组人数
- 225
- 试验地点
- 2
- 主要终点
- Clinical pregnancy rate
研究概览
简要总结
Evaluation of the effect of altering the timing of human chorionic gonadotropin (HCG) administration on the clinical pregnancy rate in intrauterine insemination (IUI) cycles.
详细描述
Women will be randomly divided into 3 groups; the first group will undergo IUI at the time HCG administration, the second group will undergo IUI 12 hours after HCG administration and the third group will undergo IUI 34-36 hours after HCG administration.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Mild male factor infertility or unexplained infertility.
排除标准
- •Advanced male factor infertility.
- •Polycystic ovary syndrome (PCOS) as defined by the Rotterdam criteria.
- •Endometriosis.
- •Tubal disease.
- •Uterine abnormalities or myoma.
- •Previous uterine surgery.
- •Metabolic or hormonal abnormalities.
研究组 & 干预措施
Group B
IUI 12 hours after HCG
干预措施: HCG (Drug)
Group C
IUI 34-36 hours after HCG
干预措施: HCG (Drug)
Group A
IUI at time of HCG
干预措施: HCG (Drug)
结局指标
主要结局
Clinical pregnancy rate
时间窗: 4-6 weeks after IUI
Number of clinical pregnancies (defined as presence of at least one intrauterine gestational sac with fetal pole and cardiac activity on TVS scan at 4-6 weeks after IUI) divided by the number of IUI cycles
次要结局
未报告次要终点
研究者
Mohamed Ibrahem Eid
Dr
Mansoura University