Different Timing of Intrauterine Insemination and Pregnancy Outcome in Patient With Unexplained Infertility :A Randomized Controlled Study
试验速览
- 阶段
- 4 期
- 入组人数
- 80
- 主要终点
- Primary outcome
研究概览
简要总结
to determine the most suitable time for administration of (human chorionic gonadotropin )hCG prior to intrauterine insemination (IUI) to optimize pregnancy outcome and to have the best success rates so the cases divided in to four groups according to the time of hCG administration .
详细描述
IUI with or without ovarian stimulation is a common treatment for infertility ,it is a simple procedure the semen is prepared in the laboratory and transferred by a catheter and injected intrauterine .ultrasound folliculometry is used for monitoring follicular growth where some clinicians prefer the natural cycles and others prefer ovarian stimulation and human chorionic gonadotropin (hCG)trigger for better timing .so cases will take induction and folliculometry will be done until the follicle reach 18mm trigger with hCG .women will be randomly divided to four groups .the first group will undergo IUI at 24 after trigger the second IUI at36 hour after trigger the thirdG at 48 after trigger and finaly the last group IUI will be done simultaneos with trigger the out come the number of pregnant women for each group.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 40 Years(Adult)
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Mild male infertility or unexplained infertility
排除标准
- •Adanced male factor endometriosis uterine abnormality sever semen parameters i impairment according to WHO 2010 non ovulatory cycles bilatral tubal block
研究组 & 干预措施
GROUP 1
IUI 24 hours after hCGadminstration
干预措施: hCG (Drug)
GROUP 2
IUI 36 hours after hCG adminstration
干预措施: hCG (Drug)
GROUP 3
IUI 48 hours after hCG adminstration
干预措施: hCG (Drug)
GROUP 4
IUI at time of hCG adminstration
干预措施: hCG (Drug)
结局指标
主要结局
Primary outcome
时间窗: 14 days after IUI
Positive serum beta hCG test
Secondary outcome
时间窗: 4 weeks after insemination
Clinical pregnancy defined as prescence of at least one Intrauterine gestational sac with fetal pole on Transvaginal scan
次要结局
未报告次要终点
研究者
Salwa Sabry Ahmed Mohamed
Faculty of medicine sohag university
Sohag University
