Intra-uterine Injection of Human Chorionic Gonadotrophin Before Embryo Transfer in ICSI
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 472
- 试验地点
- 1
- 主要终点
- implantation and pregnancy rates
研究概览
简要总结
Chorionic gonadotrophins (hCG) play an important role in implantation. The aim of the study is to evaluate the effect of intrauterine injection of hCG before embryo transfer in IVF/ICSI on the implantation and pregnancy rates. The rational is that intrauterine hCG injection will attract regulatory T cells and improve implantation.
详细描述
Background :
Human chorionic gonadotrophin ( hCG) was found to secreted immediately after fertilization by the embryo. It plays an important role in implantation and in attracting regulatory T cells to the endometrium.
Rational :
Intrauterine injection of hCG before embryo transfer in IVF/ICSI may increase endometrial regulatory T cells ( Treg ) and improve the implantation and pregnancy rates.
Aim of the work :
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 39 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •male factor infertility
- •normal female hormonal profile
- •normal uterine cavity
排除标准
- •previous ICSI failure
- •endometriosis
- •azoospermia
研究组 & 干预措施
intrauterine hCG
Experimental arm : intrauterine injection of 100 iu(group1)or 200 iu (group2) of hCG before embryo transfer.
Intrauterine injection of 500 iu hCG before embryo transfer
干预措施: human chorionic gonadotrophin (Drug)
结局指标
主要结局
implantation and pregnancy rates
时间窗: 5 weeks after embryo transfer
次要结局
- miscarriage and delivery rates(9 months from embryo transfer)
研究者
Ragaa Mansour
Director
The Egyptian IVF-ET Center