Intra Uterine Injection of Human Chorionic Gonadotropin Versus Granulocyte Colony Stimulating Factor at Ovum Pick up Day Significantly Increase Implantation Rate and Pregnancy Rate in Intra Cytoplasmic Sperm Injection
试验速览
- 阶段
- 不适用
- 入组人数
- 200
- 主要终点
- clinical pregnancy rate
研究概览
简要总结
Intrauterine Granulocyte colony stimulating factor (GCSF) was compared with intrauterine Human Chorionic Gonadotropin (HCG) in increasing clinical pregnancy rate as a primary outcome and ultrasound imaging of gestational sac as a secondary outcome.
详细描述
Two hundred females with history of recurrent implantation failure and undergoing Intracytoplasmic Sprem injection (ICSI) were randomized into two groups; the first group (100 patients) received intrauterine Granulocyte colony stimulating factor (GCSF) and the second group (100) received intrauterine Human Chorionic Gonadotropin (HCG) at ovum pick up day. The clinical pregnancy rate was evaluated as a primary outcome after 14 days and ultrasound imaging of gestational sac was evaluated as a secondary outcome after 6 weeks.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 50 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Females suffering from recurrent implantation failure and undergoing ICSI
排除标准
- •presence of comorbidity as diabetes, hypertension, heart diseases, or endocrine disorders
研究组 & 干预措施
Group 1
Granulocyte Colony Stimulated Factor was intrauterine injected once at ovum pick up day
干预措施: Granulocyte Colony Stimulated Factor (Drug)
Group 2
500 IU Human Chorionic Gonadotropins was injected intrauterine once at ovum pick up day
干预措施: Human Chorionic Gonadotropins (Drug)
结局指标
主要结局
clinical pregnancy rate
时间窗: after 14 days from positive pregnancy test
Clinical pregnancy was evaluated by high HCG levels
次要结局
- Gestational sac imaging(6 weeks of pregnancy)
研究者
Elsayed Eldesouky
Assistant professor of obstetrics and gynecology faculty of medicine Alazhar university Cairo
Al-Azhar University