Intrauterine Human Chorionic Gonadotrophins (hCG) and Endometrial Treg Cells
- Registration Number
- NCT01064219
- Lead Sponsor
- The Egyptian IVF-ET Center
- Brief Summary
Intrauterine injection of hCG around the time of implantation may increase endometrial Treg cells and improve implantation. It has been demonstrated that regulatory T cells expand during pregnancy. hCG was found to be secreted by the embryo immediately after fertilization and has chemoattractant properties to Treg cells.
- Detailed Description
Aim of the work:
To study the effect of intrauterine injection of human chorionic gonadotrophin on the endometrial T regulatory cells (Treg cells)and the electromicroscopic endometrial characteristics.
Background:
It has been demonstrated that regulatory T cells expand during pregnancy and are present at the feto-maternal interface at very early stages in pregnancy.
Rational:
Intrauterine injection of hCG around the time of implantation may increase endometrial Treg cells and improve implantation.
Methods:
Intrauterine injection of 100 IU hCG will be done followed by endometrial biopsy to check for Treg cells and pinopodes.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 20
- Male factor infertility
- Ovulatory factor infertility
- Unexplained infertility
- Female age less than 39
- Azoospermia
- Tubal factor infertility
- Pelvic endometriosis
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description intrauterine hCG human chorionic gonadotrophin intrauterine injection of 100 hCG followed by endometrial biopsy
- Primary Outcome Measures
Name Time Method the presence of Treg cells and pinopodes in the endometrium 4 weeks
- Secondary Outcome Measures
Name Time Method pregnancy rate 4 weeks
Trial Locations
- Locations (1)
Cairo University
🇪🇬Cairo, Egypt
Cairo University🇪🇬Cairo, Egypt