A clinical trial to evaluate the efficacy of midazolam co-induction in reducing the induction dose of propofol
Phase 4
- Conditions
- Health Condition 1: null- general anaesthesia for elective procedures
- Registration Number
- CTRI/2013/09/003946
- Lead Sponsor
- nil
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
any patient comming for elective surgical procedures under general anaesthesia
Exclusion Criteria
chronic use of hypnotics and analgesics,abnormal body weight[more than 20 percent difference from normal BMI,epileptics on treatment with phenytoin,pregnant and lactating,allergic to study medications,uncorrected hypotension,patient with liver disease
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method total dose of propofol in mg/kg bodywgtrecquiredin acheiving loss of verbal response and loss of motor response in trial(with midazolam co-induction) and control group(with propofol only) will be comparedTimepoint: total dose of propofol in mg/kg bodywgt recquired in time point at which loss of verbal response and loss of motor response occur
- Secondary Outcome Measures
Name Time Method comparison of mean arterial blood pressure and heart rateTimepoint: after premedication,1 minute after midazolam/normal saline,immediately after induction ,immediately after intubation,5 minutes after intubation <br/ ><br>