Comparison of the effect of tranexamic acid bolus dose with bolus followed by infusion on perioperative blood loss in adult patients undergoing brain tumour surgery
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- The amount of blood loss during surgery in millilitres
研究概览
简要总结
The antifibrinolytic effect of tranexamic acid is well established and studies support its role in cases of neurosurgery to reduce intraoperative blood loss. However, few studies have attempted to evaluate the efficacy of intravenous bolus as compared to continuous intravenous infusion of tranexamic acid in patients undergoing neurosurgery. Keeping these observation in mind, this study is being undertaken to evaluate the efficacy of intravenous bolus dose of tranexamic acid with intravenous bolus followed by continuous infusion of tranexamic acid in neurosurgery patients undergoing brain tumour surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant, Investigator and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Adult patients aged 18 to 65 years undergoing brain tumour surgery
- •American Society of Anaesthesiologists (ASA) grade I and II only.
排除标准
- •Patients who have a history of allergic reaction to tranexamic acid
- •Patients having previous documented history of thromboembolic disease
- •Patients who have documented coagulopathies diagnosed before surgery
- •Patients with documented hepatic or renal dysfunction.
结局指标
主要结局
The amount of blood loss during surgery in millilitres
时间窗: At the end of surgery i.e. skin closure has finished
次要结局
- Blood loss during surgery
研究者
Utkarsh Rathi
VMMC and Safdarjung Hospital New Delhi