Investigating the Oral Bioavailability of Vitamin C Administered Using Phosphycell™ Technology - a Phosphatidylcholine-lipid Encapsulation Technology.
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Skeletal muscle vitamin C concentrations
研究概览
简要总结
The purpose of this study is to determine if crystalline vitamin C supplementation can acutely increase skeletal muscle vitamin C concentrations and if this can be potentiated by administering vitamin C using Phosphycell™ Technology - a phosphatidylcholine-lipid encapsulation technology.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Body mass index (BMI) 18.5 - 30 kg/m2
- •Age 18 - 40
- •Non-smoker
排除标准
- •Body mass index (BMI) < 18.5 or > 30 kg/m2
- •Age < 18 or > 40
- •Cardiovascular disease
- •Hypertension (≥ 140/90 mmHg)
- •Metabolic disease
- •Medications known to affect vitamin C metabolism
- •A known vitamin C deficiency
- •Less than 2 hours per week of physical activity or following a structured exercise training program.
- •Routine use of vitamin supplements
研究组 & 干预措施
Crystalline vitamin C supplementation
1000 mg of vitamin C ingested in crystalline form
干预措施: Crystalline vitamin C (Dietary Supplement)
Phosphatidylcholine-lipid encapsulated vitamin C supplementation
1000 mg of vitamin C ingested in phosphatidylcholine-lipid encapsulated form
干预措施: Phosphatidylcholine-lipid encapsulated vitamin C (Dietary Supplement)
结局指标
主要结局
Skeletal muscle vitamin C concentrations
时间窗: 12 hours after vitamin C ingestion
Skeletal muscle vitamin C concentrations 12 hours after vitamin C ingestion will be measured using HPLC and compared to baseline and 6 hours after vitamin C ingestion
Skeletal muscle vitamin C concentrations
时间窗: 6 hours after vitamin C ingestion
Skeletal muscle vitamin C concentrations 6 hours after vitamin C ingestion will be measured using HPLC and compared to baseline
次要结局
- Blood plasma vitamin C concentrations(24 hours after vitamin C ingestion)
- White blood cell vitamin C concentrations(24 hours after vitamin C ingestion)
- Cardiovascular function(24 hours after vitamin C ingestion)
- White blood cell vitamin C concentrations(6 hours after vitamin C ingestion)