Effects of vitamin D3 supplementation on oxidative and inflammatory stress markers in overweight or obese workers

Not Applicable

• Conditions: Obesity; C18.654.726.500

• Registration Number: RBR-39srtp
• Lead Sponsor: niversidade Federal da Paraíba

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-06-03
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Data analysis completed
• Sex: Female
• Target Recruitment: Not specified

Inclusion Criteria

women aged between 18 and 59 years; have vitamin D deficiency or insufficiency; have a Body Mass index greater than 25 kg / m²; do not take any vitamin D supplementation; not taking anticonvulsants or medications to treat the human immunodeficiency virus or acquired immunodeficiency syndrome; not having a diagnosis of Type I Diabetes Mellitus, nephrotic syndrome, acute or chronic kidney disease, liver disease, hypothyroidism, hyperthyroidism, history of stroke or acute myocardial infarction in the last 6 months; do not drink alcoholic beverages; do not smoke

Exclusion Criteria

Women with previous vitamin D use; women under 18 or over 59; women using anticonvulsants or medications to treat the human immunodeficiency virus or acquired immunodeficiency syndrome; women diagnosed with Type I Diabetes Mellitus, nephrotic syndrome, acute or chronic kidney disease, liver disease, hypothyroidism, hyperthyroidism, history of stroke or acute myocardial infarction in the last 6 months; Alcoholic women; smoking women.

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Assess serum vitamin D levels after vitamin D3 megadose supplementation. It is expected to find increased serum levels after 4 weeks of supplementation. Serum vitamin D levels were assessed by chemiluminescent immunoassay. A significant increase in serum vitamin D levels was observed from 23.8 IU pre-intervention to 31.7 IU after intervention (p <0.05) in the intervention group. The serum vitamin D levels in the placebo group were similar (pre: 24.1 vs. post: 22.3, p> 0.05).